Cell-cell communication and network function

We use the both the top-down and bottom-up synthesis approach to synthesize new materials and nanostructures to investigate the biophysical properties of tissue and cells. We are mainly interested in the mechanism by which cellular arrangement communicate. The grand goal will be designing an artificial tissue that incorporates inorganic elements – A SMART TISSUE!

For example, Si nanowires and graphene are the building blocks that we synthesize and incorporate in our research as ultrasensitive sensors. Moreover, we develop new approaches to manipulate cells and design our SMART TISSUE.

Our previous attempts to connect the soft world of biology, such as cells and tissue, with nanoscale devices are described in the following images. Indeed we will even push it further and blur the distinction between the digital world and the biological world!

Gra_SiNW_v1A basic flexible interface of SiNW and graphene with cardiomyocyte

short_channel_v1Pushing the limits of nanoelectronics interfaces with cells, a device as small as a few protein molecules across measures electrical activity of a cardiomyocyte at an exquisite spatio-temporal resolution

3D_nanoProbe_v1A breakthrough design of cell-nanodevice interface, a unique three-dimensional device for the FIRST intracellular recordings of actions potential, the first demonstration of a nanoscale cyborg!