We develop complex nanostructured topologies for cellular interfaces and investigations. Using a bottom-up approach, we plan to design and synthesize nanomaterials-based platforms that allow tailoring of the materials’ optical, electrical and chemical properties. This approach will allow a unique formation of structures in one-, two- and three-dimensional geometries that will be used in further experimental designs.
The rationale behind incorporating nanostructures and forming a nano composite material is to compensate for materials intrinsic limitations such as mechanical properties, electrical conductivity, the absence of adhesive and microenvironment-defining moieties, and the inability of cells to self-assemble to three-dimensional tissues.
The conceptualized nanostructured platform for cellular interfaces. The interface can be altered at the molecular level by immobilizing molecules on the nanostructures
Human mesenchymal stem cells (hMSC) cultured on nanocomposite nanofibers