Cell-nanostructure interactions

We develop complex nanostructured topologies for cellular interfaces and investigations. Using a bottom-up approach, we plan to design and synthesize nanomaterials-based platforms that allow tailoring of the materials’ optical, electrical and chemical properties. This approach will allow a unique formation of structures in one-, two- and three-dimensional geometries that will be used in further experimental designs.

The rationale behind incorporating nanostructures and forming a nano composite material is to compensate for materials intrinsic limitations such as mechanical properties, electrical conductivity, the absence of adhesive and microenvironment-defining moieties, and the inability of cells to self-assemble to three-dimensional tissues.

nano_fibers_v1The conceptualized nanostructured platform for cellular interfaces. The interface can be altered at the molecular level by immobilizing molecules on the nanostructures

nano_fibers_2_v1Human mesenchymal stem cells (hMSC) cultured on nanocomposite nanofibers